抗BCL2L1抗體(anti-BCL2L1antibody)

　　名稱：抗BCL2L1抗體(anti-BCL2L1 antibody)

　　貨號：FNab00842

　　適應種屬：人源，小鼠

　　規格：100ug(微克)

　　狀態：液體

　　純化方法：免疫親和純化

　　純度：經sds-page分析，純度大于95

　　宿主：兔

　　亞型：IgG

　　存儲：用添加了0.02疊氮化鈉和50甘油的pbs溶解，ph值7.3，可在-20℃下保存12個月（避免反復凍融）

　　免疫原：BCL2-like 1

　　免疫原別稱：BCL2L, BCLX

　　分子量：30 kDa

　　驗證應用：ELISA, IHC, IP, IF, WB

　　建議稀釋比例：WB: 1:1000-1:6000; IP: 1:500-1:3000; IHC: 1:50-1:500; IF: 1:50-1:500

　　克隆性：多克隆

　　UniProt ID：Q07817

　　背景介紹：Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel(VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release(PubMed:17418785). Isoform Bcl-X(S) promotes apoptosis。

　　Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using FNab00842(BCL2L1 antibody) at dilution of 1:100。

　　IP result of anti-BCL2L1(IP:FNab00842, 3ug; Detection:FNab00842 1:500) with K-562 cells lysate 8000 ug。