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| 產(chǎn)品參數(shù) | |||
|---|---|---|---|
| 品牌 | 菲恩生物 | ||
| 適用范圍 | 僅供科研使用 | ||
| 規(guī)格 | 100μg | ||
| 加工定制 | 否 | ||
| 驗證應(yīng)用 | ELISA | ||
| WB | |||
| IHC | |||
| IF | |||
| 宿主 | 兔 | ||
| 適應(yīng)種屬 | 人源，大鼠，小鼠 | ||
| 研究領(lǐng)域 | 信號傳導，心血管生物學，新陳代謝，表觀遺傳學 | ||
| 可售賣地 | 全國 | ||
| 材質(zhì) | 液體 | ||
名稱：抗TRIM63抗體(anti- TRIM63 antibody)
貨號：FNab08992
適應(yīng)種屬：人源，大鼠，小鼠
規(guī)格：100ug(微克)
狀態(tài)：液體
純化方法：免疫親和純化
純度：經(jīng)sds-page分析,純度大于95
宿主：兔
亞型：igg
存儲：用添加了0.02疊氮化鈉和50甘油的pbs溶解,ph值7.3,可在-20℃下保存12個月（避免反復凍融）
免疫原：tripartite motif-containing 63
免疫原別稱：FLJ32380, IRF, Iris RING finger protein, MuRF 1, MURF1, MURF2, RING finger protein 28, RNF28, SMRZ, TRIM63, tripartite motif containing 63
分子量：40 kDa
驗證應(yīng)用：ELISA, WB, IHC, IF
建議稀釋比例：WB: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:10-1:100
克隆性：多克隆
uniprot id：Q969Q1
背景介紹：E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells。
圖像：
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Immunohistochemistry of paraffin-embedded human heart using FNab08992(TRIM63 antibody) at dilution of 1:50。
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Immunofluorescent analysis of HeLa cells using FNab08992 (TRIM63 antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IgG。
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mouse heart tissue were subjected to SDS PAGE followed by western blot with FNab08992(TRIM63 antibody) at dilution of 1:300。
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